Polytherapy and drug interactions in elderly

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Polytherapy and drug interactions in elderly

There is an increase in population of elderly above the age of 65. As age advances, more diseases develop resulting in use of more medications. Physiological changes, alterations in homeostatic regulation and diseases modify pharmacokinetics and drug response in older patients. The risk for drug interactions and drug-related problems increases along with multiple medications. Periodic evaluatio...

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While several newer AEDs have study data that support monotherapy usage, most possess FDA indications for adjunctive treatment of partial onset seizures, leading to their initial (and often persistent) clinical use as adjunctive polytherapy for patients with refractory epilepsy. This review considers a practical approach to the appropriate role for polytherapy in epilepsy, presents the evidence...

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Significant drug interactions in dermatology

Systemic drugs have been used widely in the treatment of many skin diseases. Although dermatologists are familiar with the guidelines of selecting appropriate patients and prescribing systemic drugs, their knowledge about the side effects and significant interactions of systemic drugs used in dermatology is more limited. So a short review on important drug interactions seems to be useful. Some ...

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Drug-drug interactions in a cohort of hospitalized elderly patients.

PURPOSE The aim of this study is to assess the prevalence of patients exposed to potentially severe drug-drug interactions (DDIs) at hospital admission and discharge and the related risk of in-hospital mortality and adverse clinical events, readmission, and all-cause mortality at 3 months. METHODS This cross-sectional, prospective study was held in 70 Italian internal medicine and geriatric w...

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Drug-drug interactions among elderly patients hospitalized for drug toxicity.

CONTEXT Drug-drug interactions are a preventable cause of morbidity and mortality, yet their consequences in the community are not well characterized. OBJECTIVE To determine whether elderly patients admitted to hospital with specific drug toxicities were likely to have been prescribed an interacting drug in the week prior to admission. DESIGN Three population-based, nested case-control stud...

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ژورنال

عنوان ژورنال: Journal of Mid-life Health

سال: 2016

ISSN: 0976-7800

DOI: 10.4103/0976-7800.191021