منابع مشابه
Polysialic acid enhances the migration and invasion of human cytotrophoblasts.
Polysialic acid (polySia) is a large, cell-surface linear homopolymer composed of α2,8-linked sialic acid residues. Most extensively studied in the nervous system, this unique glycan modulates development by enhancing cell migration and regulating differentiation. PolySia also functions in developing and adult immune systems and is a signature of many cancers. In this study, we demonstrated tha...
متن کاملCMP substitutions preferentially inhibit polysialic acid synthesis.
It is widely reported that derivatives of sugar moieties can be used to metabolically label cell surface carbohydrates or inhibit a particular glycosylation. However, few studies address the effect of substitution of the cytidylmonophosphate (CMP) portion on sialyltransferase activities. Here we first synthesized 2'-O-methyl CMP and 5-methyl CMP and then asked if these CMP derivatives are recog...
متن کاملFatty acid composition of Taiwanese human milk.
BACKGROUND The purpose of this study was to analyze quantitatively the fatty acid composition of the milk of Taiwanese women. METHODS Two hundred and sixty-nine human milk specimens were obtained from 240 Taiwanese mothers, aged 19-41 years, and subjected to chromatographic analysis. RESULTS Milk specimens were pooled by the mothers' districts of residence and lactation stages, at 0-11 days...
متن کاملAmino acid composition of human milk.
The fundamental importance of human milk in infant nutrition makes it desirable to have available as complete information as possible on the amounts of amino acids contributed to the diet from this source (Williamson (l), Block and Bolling (2, 3), and Macy (4)). In the present study, hydrolysates of human milk have been analyzed by ion exchange chromatography (Moore and Stein (5)) as applied in...
متن کاملExtended Polysialic Acid Chains ( n > 55 ) in Glycoproteins from Human Neuroblastoma Cells
Polysialic acid-containing glycoproteins consisting of extended chains of at least 55 sialyl residues (DP55, where DP represents degree of polymerization) are expressed on human neuroblastoma cells, CHP134. The strategy used for detecting these unique carbohydrate structures was based on the use of two highly specific prokaryotic-derived enzyme systems and an anti-polysialosyl antibody (H.46). ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2003
ISSN: 0021-9258
DOI: 10.1074/jbc.m300458200