Polysaccharide Nanoparticles Can Efficiently Modulate the Immune Response against an HIV Peptide Antigen

IpaD-loaded N-trimethyl Chitosan Nanoparticles Can Efficiently Protect Guinea Pigs against Shigella Flexneri

Background: Shigella flexneri is a pathogen responsible for shigellosis around the world, especially in developing countries. Many immunogenic antigens have been introduced as candidate vaccines against Shigella, including N-terminal region of IpaD antigen (NIpaD). Objective: To evaluate the efficiency of O-metylated free trimethyl chitosan na...

Can the immune response control HIV infection?

Human immunodeficiency virus (HIV) constitutes an unprecedented challenge to medical science. Once an HIV infection is established, its clinical course, while protracted , is generally inexorable. With the possible exception of a group of recently described "long-term nonpro-gressors," virtually all HIV-infected individuals eventually develop acquired immunodeficiency syndrome (AIDS), the outco...

Evaluation of Cellular Immune Response against Purified Antigen 85 in Patients with Tuberculosis

Background: Tuberculosis (TB) remains an important health problem throughout the world. Despite its significance in public health, mechanisms of protective immunity against Mycobacyerium Tuberculosis in humans have not yet been understood. Objective: To evaluate cell mediated immune response against purified Ag 85, PPD and Phytohemagglutinin (PHA) in patients with tuberculosis and healthy tuber...

Antigen-pulsed dendritic cells can efficiently induce an antibody response in vivo

The aim of this study was to develop an immunization procedure avoiding external adjuvant. Data are presented showing that syngeneic dendritic cells (DC), which have been pulsed in vitro with antigen, induce a strong antibody response in mice. By contrast, antigen (Ag)-pulsed low-density B cells, although equally able to induce interleukin 2 secretion by an Ag-specific T cell hybridoma in vitro...

Carnauba Wax Nanoparticles Enhance Strong Systemic and Mucosal Cellular and Humoral Immune Responses to HIV-gp140 Antigen Running title: Nanoparticles enhance immune responses to HIV-gp140 antigen