(Poly)phenols protect from α-synuclein toxicity by reducing oxidative stress and promoting autophagy
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چکیده
منابع مشابه
Progesterone and Cilostazol Protect mice pancreatic islets from oxidative stress induced by hydrogen peroxide
Abstract Reactive oxygen species and oxidative stress impair β-cell function and reduce insulin secretion. It has been shown that progesterone and cilostazol possess antioxidant properties. The present study was aimed to investigate in vitro pretreatment effect of progesterone and cilostazol on insulin secretion as well as their protective effects against hydrogen peroxide-induced oxidative str...
متن کاملProgesterone and Cilostazol Protect mice pancreatic islets from oxidative stress induced by hydrogen peroxide
Abstract Reactive oxygen species and oxidative stress impair β-cell function and reduce insulin secretion. It has been shown that progesterone and cilostazol possess antioxidant properties. The present study was aimed to investigate in vitro pretreatment effect of progesterone and cilostazol on insulin secretion as well as their protective effects against hydrogen peroxide-induced oxidative str...
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Parkinson’s Disease is a neurodegenerative disease that is pathologically characterized by abnormal α-synuclein protein aggregation, dopamine depletion in nigrostriatal neurons, and the subsequent death of these neurons. Oxidative stress has been widely implicated as a cause for neurodegenerative diseases, especially Parkinson’s Disease (PD). The mechanisms by which oxidative stress occurs in P...
متن کاملTFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity.
The aggregation of α-synuclein plays a major role in Parkinson disease (PD) pathogenesis. Recent evidence suggests that defects in the autophagy-mediated clearance of α-synuclein contribute to the progressive loss of nigral dopamine neurons. Using an in vivo model of α-synuclein toxicity, we show that the PD-like neurodegenerative changes induced by excess cellular levels of α-synuclein in nigr...
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Oxidative stress has been proposed to play a key role in malignant hyperthermia (MH), a syndrome caused by excessive Ca2+ release in skeletal muscle. Incidence of mortality in male calsequestrin-1 knockout (CASQ1-null) mice during exposure to halothane and heat (a syndrome closely resembling human MH) is far greater than that in females. To investigate the possible role of sex hormones in this ...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2014
ISSN: 1460-2083,0964-6906
DOI: 10.1093/hmg/ddu585