Polyphenolic Profile, Antioxidant and Antidiabetic Potential of Medlar (Mespilus germanica L.), Blackthorn (Prunus spinosa L.) and Common Hawthorn (Crataegus monogyna Jacq.) Fruit Extracts from Serbia

Plant-based food represents an excellent source of different nutrients and bioactive compounds, such as phenolics, carotenoids, vitamins, etc., with proven health benefits for humans. The content selected phytochemicals, polyphenolic profile, biological activity (antioxidant potential ?-glucosidase inhibitory activity) fruit extracts medlar (Mespilus germanica L.), blackthorn (Prunus spinosa common hawthorn (Crataegus monogyna Jacq.), the neglected Rosaceae species originated from Serbia were studied. Targeted UHPLC/(?)HESI–MS/MS quantitative analysis phenolic compounds revealed pinocembrin only in extract, it is first report this flavanone fruits. Total did not differ between extracts, whereas significant differences observed contents total flavonoids, acids, gallotannins. Monomeric anthocyanins significantly higher compared to (p < 0.05). DPPH? ABTS?+ scavenging activities examined fruits modest other natural antioxidants BHT. most potent toward expressed IC50 values 129.46 199.84 ?g/mL, respectively, which was standard drug acarbose.