(Poly)phenolic compounds and gut microbiome: new opportunities for personalized nutrition

For decades, (poly)phenols have been linked to cardiometabolic health, but population heterogeneity limits their apparent efficacy and the development of tailored, practical protocols in dietary interventions. This is likely determined by existence different metabotypes, sub-populations individuals metabolizing some classes differently. The gut microbiota plays a major role this process. impact microbiota-related phenolic metabotypes on health becoming evident, although picture still incomplete, data are absent for (poly)phenols. lack complete understanding main microbial actors involved process complicates picture. Elucidation mechanisms behind requires novel experimental designs that can dissect inter-individual variability. paper, addition providing an overview current state-of-the-art, proposes wider metabotyping approaches as means paving way towards effective personalized nutrition with