Polyneuropathy associated with levodopa/carbidopa intestinal gel infusion (LCIG)
نویسندگان
چکیده
منابع مشابه
Chronic inflammatory demyelinating polyneuropathy associated with intestinal tuberculosis.
Chronic inflammatory demyelinating polyneuropathy (CIDP) is an increasingly common but under-recognized neurological disorder. It is immune mediated, and usually has a relapsing and remitting course. However, the initial presentation may be rapid. It can be associated with significant morbidity and mortality, particularly if there is a delay in diagnosis and treatment. It has been associated wi...
متن کاملLevodopa-carbidopa intestinal gel for treatment of advanced Parkinson's disease.
BACKGROUND Levodopa is the mainstay of Parkinson's disease (PD) treatment, but is often eventually associated with disabling motor complications in patients with advanced PD. The inability of perorally administered levodopa to provide more physiologic continuous dopaminergic stimulation (CDS) is a leading hypothesis to explain these complications. OBJECTIVE To investigate the cumulative effic...
متن کاملLevodopa-Carbidopa Intestinal Gel Pharmacokinetics: Lower Variability than Oral Levodopa-Carbidopa
In a double-blind, double-dummy, double-titration Phase 3 trial in advanced Parkinson's disease (PD) patients, the efficacy and safety of Levodopa-carbidopa intestinal gel (LCIG) infusion were characterized relative to immediate-release oral levodopa-carbidopa (LC-oral) treatment. We present in this report the comparative pharmacokinetic profiles of LCIG and LC-oral from this pivotal study. The...
متن کاملLevodopa-carbidopa intestinal gel (LCIG) treatment in routine care of patients with advanced Parkinson's disease: An open-label prospective observational study of effectiveness, tolerability and healthcare costs.
BACKGROUND Continuous infusion of levodopa-carbidopa intestinal gel (LCIG) can effectively manage motor and non-motor complications in advanced Parkinson's disease (PD). Healthcare costs, quality of life (QoL), effectiveness, and tolerability were assessed in routine care treatment with LCIG. METHODS The seventy-seven patients enrolled in this prospective, open-label, 3-year study in routine ...
متن کاملAutoimmune hepatitis associated with motor-axonal polyneuropathy.
antibody and rheumatoid factor were not found. Biochemical screening for viral hepatitis did not reveal antibodies against any type of viral hepatitis. Immunofixation was normal and cryoglobulins were not detected. Histological evaluation of liver biopsy demonstrated macronodular cirrhosis, portal tract fibrosis and proliferating biliary tracts with infiltrates of mainly T lymphocytes and few p...
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ژورنال
عنوان ژورنال: Neurologie pro praxi
سال: 2020
ISSN: 1213-1814,1803-5280
DOI: 10.36290/neu.2020.025