Polymyxin-B hemoperfusion inactivates circulating proapoptotic factors
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چکیده
منابع مشابه
Polymyxin B hemoperfusion: a mechanistic perspective
Direct hemoperfusion therapy with polymyxin B immobilized fiber cartridge (PMX-DHP) is an established strategy in the treatment of septic shock in Japan and parts of Western Europe. PMX-DHP is currently the subject of a pivotal North American randomized controlled trial (EUPHRATES) in patients with septic shock and confirmed endotoxemia, as measured by the endotoxin activity assay. The major me...
متن کاملPolymyxin B-immobilized fiber column hemoperfusion therapy for septic shock.
Endotoxin, an outer membrane component of gram-negative bacteria, plays an important role in the pathogenesis of septic shock. Endotoxin adsorption therapy by polymyxin B-immobilized fiber column hemoperfusion (PMX) has been used for the treatment of septic shock patients in Japan since 1994. The covalent binding of polymyxin B onto the surface of the polystyrene-based carrier fiber in PMX inac...
متن کاملPolymyxin B Hemoperfusion for Septic Shock -- Ready for Primetime? Early Use of Polymyxin B Hemoperfusion in Abdominal Septic Shock: The EUPHAS Randomized Controlled Trial
Background: Treatments for severe sepsis are limited, and its morbidity and mortality, especially from Gramnegative organisms, continues to be significant. Gram-negative organisms release endotoxin, which initiates inflammatory and coagulation cascades, resulting in end-organ dysfunction in patients. Polymyxin B hemoperfusion filters bind endotoxin. Objective: To assess the efficacy of polymyxi...
متن کاملDirect hemoperfusion using polymyxin-B immobilized fiber for septic shock after cardiac surgery.
BACKGROUND The factors contributing to the efficacy and outcome of direct hemoperfusion using polymyxin-B immobilized fiber (PMX-DHP) after cardiac surgery were investigated. METHODS AND RESULTS In 23 patients who received PMX-DHP for shock related to infection after cardiac surgery, there were no differences in the pre- and intraoperative clinical data of survivors (n=14) and non-survivors (...
متن کاملPolymyxin-B-immobilized-fiber column hemoperfusion with oseltamivir treatment for ARDS due to influenza H1N1/09
Acute respiratory distress syndrome (ARDS) is one of the severe complications of influenza H1N1/09 infection, resulting in high mortality. Effective treatment strategies for ARDS are needed. This report presents two cases of ARDS due to influenza in Vietnam. Both cases were similar in terms of starting symptoms, the rapid progression to ARDS, and the treatment strategy, direct hemoperfusion wit...
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ژورنال
عنوان ژورنال: Intensive Care Medicine
سال: 2008
ISSN: 0342-4642,1432-1238
DOI: 10.1007/s00134-008-1124-6