Polymorphisms of the Methylene Tetrahydrofolate Reductase and Susceptibility to Acute Lymphoblastic Leukemia in Children
نویسندگان
چکیده
منابع مشابه
Polymorphisms in the methylene tetrahydrofolate reductase and methionine synthase reductase genes and their correlation with unexplained recurrent spontaneous abortion susceptibility.
We aimed to explore the correlation between unexplained recurrent spontaneous abortion and polymorphisms in the methylene tetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) genes. A case control study was conducted in 118 patients with unexplained recurrent spontaneous abortion (abortion group) and 174 healthy women (control group). The genetic material was extracted fr...
متن کاملassociation between methylenetetrahydrofolate reductase (mthfr) gene polymorphisms and susceptibility to childhood acute lymphoblastic leukemia in an iranian population
background: the present study was aimed to examine the possible association between methylene tetrahydrofolate reductase (mthfr) gene polymorphisms and childhood acute lymphoblastic leukemia (all) in a sample of iranian population. subjects and methods: a total of 220 subjects including 100 children diagnosed with all and 120 healthy children participated in the case-control study. the single n...
متن کاملPolymorphisms in CYP1A1 and ethnic-specific susceptibility to acute lymphoblastic leukemia in children.
BACKGROUND Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. The U.S. Surveillance Epidemiology and End Results (SEER) registry reports that Hispanic children have the highest incidence of ALL, however, it is unclear if this is due to genetic factors, unique environmental exposures, or both. Previous reports have shown an association between CYP1A1 variants and ALL. ...
متن کاملAssociation Between PIP4K2A Polymorphisms and Acute Lymphoblastic Leukemia Susceptibility
Acute lymphoblastic leukemia (ALL) is one of the most common pediatric cancers in the world. Several single-nucleotide polymorphisms (SNPs) locating at PIP4K2A locus were identified to be associated with ALL susceptibility through genome-wide association studies, however, followed by inconsistent reports in replication studies. In this study, we conducted a meta-analysis to investigate the asso...
متن کامل[Mutations in the methylene-tetrahydrofolate reductase gene and Down syndrome].
Down syndrome (DS) is a complex genetic and metabolic disorder attributed to the presence of three copies of chromosome 21. The extra chromosome derives from the mother in 93% of cases and is due to abnormal chromosome segregation during meiosis (nondisjunction). Except for advanced age at conception, maternal risk factors for meiotic nondisjunction are not well established. A recent preliminar...
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ژورنال
عنوان ژورنال: Laboratory Medicine
سال: 2011
ISSN: 0007-5027,1943-7730
DOI: 10.1309/lm7bftez98zzmwpq