Polymorphisms of Catechol-O-Methyl Transferase (COMT) Gene in Vulnerability to Levodopa-Induced Dyskinesia
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چکیده
منابع مشابه
Docking Based De novo Design of Few Tolcapone Derivatives as Catechol-o- Methyl Transferase (Comt) Inhibitors
Catechol-O-methyl tranferase (COMT; E.C.2.1.1.6) is widely distributed enzyme in nature that plays an essential role in the metabolism of catechol neurotransmitters and catechol linked foreign entities. As L-DOPA, a key medicine in Parkinsonism is being catabolised by COMT, this justified the interest in developing improved COMT inhibitors as significant adjunct to L-DOPA therapy. Although tolc...
متن کاملCatechol-O-methyl transferase and schizophrenia.
Catechol-O-methyl transferase (COMT) is an enzyme involved in the degradation of dopamine. The most commonly examined polymorphism within the COMT gene is Val108/158Met polymorphism, which results in three to fourfold difference in COMT enzyme activity. It is particularely important in prefrontal cortex, since COMT activity is the most important regulator of the prefrontal dopamine function. Gi...
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background : a single nucleotide variation within atechol-o-methyl transferase (comt) gene may alter the comt enzyme activity level. polymorphism of val158met in the comt gene has been related to malignancy. in this regard, a study was carried out to find a possible association between the comt gene polymorphism in patients with sporadic prostate cancer (pca) and benign prostatic hyperplasia (...
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INTRODUCTION Fibromyalgia is a rheumatic syndrome characterized by diffuse and chronic pain associated with fatigue, sleep disorders, anxiety, depression, memory loss, and dizziness. Although the physiological mechanisms that control fibromyalgia have not been precisely established, neuroendocrine, genetic or molecular factors may be involved in fibromyalgia. OBJECTIVE The aim of the present ...
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Catechol-O-methyl transferase (COMT) plays a key role in the degradation of brain dopamine (DA). Specifically, low COMT activity results in higher DA levels in the prefrontal cortex (PFC), thereby reducing the vulnerability for attentional and cognitive deficits in both psychotic and healthy individuals. COMT activity is markedly reduced by a non-synonymous single-nucleotide polymorphism (SNP) ...
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ژورنال
عنوان ژورنال: Journal of Pharmacy & Pharmaceutical Sciences
سال: 2018
ISSN: 1482-1826,1482-1826
DOI: 10.18433/jpps29903