Polymorphisms in MHC class I molecules influence their interactions with components of the antigen processing and presentation pathway
نویسندگان
چکیده
Abstract MHC class I (MHC‐I) molecules undergo an intricate folding process in order to pick up antigenic peptide present the immune system. In recent years, discovery of a new editor for MHC‐I has added extra level complexity our understanding how presentation is regulated. On top this, incredible diversity leads significant variation interaction between and components antigen processing pathway. Here, we review current regarding polymorphisms human leukocyte influence their interactions with key A deeper this may offer insights apparently subtle can have impact on susceptibility disease.
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ژورنال
عنوان ژورنال: International Journal of Immunogenetics
سال: 2021
ISSN: ['1744-3121', '1744-313X']
DOI: https://doi.org/10.1111/iji.12546