Polymorphisms at the G72/G30 Gene Locus, on 13q33, Are Associated with Bipolar Disorder in Two Independent Pedigree Series*

Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series.

Linkage evidence suggests that chromosome 13 (13q32-33) contains susceptibility genes for both bipolar disorder and schizophrenia. Recently, genes called "G72" and "G30" were identified, and polymorphisms of these overlapping genes were reported to be associated with schizophrenia. We studied two series of pedigrees with bipolar disorder: the Clinical Neurogenetics (CNG) pedigrees (in which lin...

Evidence of a predisposing locus to bipolar disorder on Xq24-q27.1 in an extended Finnish pedigree.

An X-chromosomal predisposing locus to manic-depressive illness has been suggested since 1969 on the basis of the cosegregation of this trait in some families with phenotypic markers, such as color blindness, the glucose-6-phosphate dehydrogenase deficiency, and the coagulation factor IX deficiency. However, the conclusive evidence and the exact location of the putative X-chromosomal locus have...

Functional Profiling of Single- Nucleotide Polymorphisms Associated with Bipolar Disorder

Polymorphisms in the ICAM gene locus are not associated with breast cancer Risk.

In a recent case-control study which examined >25,000 single nucleotide polymorphisms (SNP), the intercellular adhesion molecule (ICAM) locus was proposed as a susceptibility locus for breast and prostate cancer (1). The genes ICAM1, ICAM4 , and ICAM5 are all located within a 20 kb region of high linkage disequilibrium of chromosome 19p13.2. We examined the association of three previously impli...

Polymorphisms in the Hsp70 gene locus are genetically associated with systemic lupus erythematosus

BACKGROUND Heat shock proteins (Hsps) play a role in the delivery and presentation of antigenic peptides and are thought to be involved in the pathogenesis of multifactorial diseases. OBJECTIVE To investigate genes encoding cytosolic Hsp70 proteins for associations of allelic variants with systemic lupus erythematosus (SLE). METHODS Case-control studies of two independent Caucasian SLE coho...