Polymorphism of γ-aminobutyric Acid Transaminase (GABAT) in Japanese
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چکیده
منابع مشابه
Elevation of y=Aminobutyric Acid in Brain: Selective Inhibition of y-Aminobutyric-a-ketoglutaric Acid Transaminase*
The quantitative measurement of amino acids in different areas of the central nervous system has shown that a progressive increase takes place in levels of y-aminobutyric acid during development (2, 3), and that the concentration of this amino acid in adult brain is relatively constant under a variety of physiological stresses. y-Aminobutyric acid is synthesized by glutamic acid decarboxylase, ...
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Since the cloning of the first γ-aminobutyric acid (GABA) transporter (GAT1; SLC6A1) from rat brain in 1990, more than 50 published studies have provided structure-function information on investigator-designed rat and mouse GAT1 mutants. To date, more than 200 of 599 GAT1 residues have been subjected to mutagenesis experiments by substitution with different amino acids, and the resulting transp...
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Social anxiety disorder (SAD) is the one of the most common anxiety disorders. Despite its high prevalence, the disorder is still considerably undiagnosed and untreated. The disease places a massive burden on patient’s lives, affecting not only their social interactions but also their educational and professional activities, thereby constituting a severe disability. γ-aminobutyric acid (GABA) s...
متن کاملConformation of the neurotransmitter γ-aminobutyric acid in liquid water.
We study the conformation and reorientation dynamics of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) under neutral and acidic conditions using a combination of broadband dielectric relaxation spectroscopy and polarization-resolved femtosecond mid-infrared pump-probe spectroscopy. We find that both zwitterionic and cationic GABA adopt nearly linear conformations in aqueous solution...
متن کاملGenetic manipulation of the γ-aminobutyric acid (GABA) shunt in rice: overexpression of truncated glutamate decarboxylase (GAD2) and knockdown of γ-aminobutyric acid transaminase (GABA-T) lead to sustained and high levels of GABA accumulation in rice kernels.
Gamma-aminobutyric acid (GABA) is a non-protein amino acid commonly present in all organisms. Because cellular levels of GABA in plants are mainly regulated by synthesis (glutamate decarboxylase, GAD) and catabolism (GABA-transaminase, GABA-T), we attempted seed-specific manipulation of the GABA shunt to achieve stable GABA accumulation in rice. A truncated GAD2 sequence, one of five GAD genes,...
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ژورنال
عنوان ژورنال: Journal of the Anthropological Society of Nippon
سال: 1984
ISSN: 0003-5505,1884-765X
DOI: 10.1537/ase1911.92.33