Polymerizable Vancomycin Derivatives for Bactericidal Biomaterial Surface Modification: Structure−Function Evaluation

Polymerizable Vancomycin Derivatives for Bactericidal Biomaterial Surface Modification: Structure−Function Evaluation

Surface modification of implantable biomaterials with biologically active functionalities, including antimicrobials, has wide potential for addressing implant-related design problems. Here, four polymerizable vancomycin derivatives bearing either acrylamide or poly(ethylene glycol) (PEG)-acrylate were synthesized and then polymerized through a surface-mediated reaction. Functionalization of van...

Inhibition of Staphylococcus epidermidis Biofilms Using Polymerizable Vancomycin Derivatives

BACKGROUND Biofilm formation on indwelling medical devices is a ubiquitous problem causing considerable patient morbidity and mortality. In orthopaedic surgery, this problem is exacerbated by the large number and variety of material types that are implanted. Metallic hardware in conjunction with polymethylmethacrylate (PMMA) bone cement is commonly used. QUESTIONS/PURPOSES We asked whether po...

Adhesive Bonding to Dentin Improved by Polymerizable Cyclodextrin Derivatives

The objective of this work was to determine bonding characteristics of a hydrophilic monomer formulation containing polymerizable cyclodextrin derivatives. The hypothesis was that a formulation containing hydrophilic cross-linking diluent comonomers and cyclodextrins with functional groups attached by hydrolytically stable ether linkages could form strong adhesive bonds to dentin. The previousl...

Bactericidal activity of vancomycin in cerebrospinal fluid.

Intraventricular application of vancomycin is an effective therapeutic regimen for the treatment of shunt-associated staphylococcal ventriculitis. We examined the in vitro activity of vancomycin at high concentrations against Staphylococcus aureus ATCC 25923 and Staphylococcus epidermidis ATCC 12228 in human cerebrospinal fluid samples. Time-kill curves revealed equal efficacies for concentrati...

Biomaterial surface modification of titanium and titanium alloys for medical applications