Polymeric Nanoneedle Arrays Mediate Stiffness‐Independent Intracellular Delivery (Adv. Funct. Mater. 3/2022)

A Highly Dense Nanoneedle Array for Intracellular Gene Delivery

We present a dense needle array with sharp nano-tips for intracellular gene and drug delivery, with the ultimate goal of gene correction in a high throughput manner. The nanoneedles are fabricated using isotropic dry etching of silicon, followed by anisotropic dry etching and thermal-oxidation-based tip sharpening. The nanoneedle density is as large as 10 needles per square centimeter. In-vitro...

Materials and Wireless Microfluidic Systems for Electronics Capable of Chemical Dissolution on Demand (Adv. Funct. Mater. 92015)

Fabrication of polymeric microneedle arrays containing Amphotericin-B for transdermal drug delivery

Background and Aim: Drug delivery through the microneedle array has been considered as an easy and non-invasive method in recent years. The purpose of this study was to design and construct an array of biodegradable polymeric microneedles containing Amphotericin-B to introduce this system and its use in the treatment of cutaneous lesions caused by Leishmania major parasite inoculation as a mode...

Metamaterials: Snapping Mechanical Metamaterials under Tension (Adv. Mater. 39/2015).

By exploiting snap-through instabilities, D. Pasini and co-workers design a damage-tolerant mechanical metamaterial that snaps sequentially under tension, thereby accommodating a very large deformation up to 150%. On page 5931, they describe how the nonlinear mechanical response of the metamaterial can be robustly programmed by tuning the architecture of its unit cell.

Characterization of Polymeric Microneedle Arrays for Transdermal Drug Delivery

Microfabrication of dissolvable, swellable, and biodegradable polymeric microneedle arrays (MNs) were extensively investigated based in a nano sensitive fabrication style known as micromilling that is then combined with conventional micromolding technique. The aim of this study was to describe the polymer selection, and optimize formulation compounding parameters for various polymeric MNs. Inve...