Polymeric Nanocarriers: A Transformation in Doxorubicin Therapies

Doxorubicin, a member of the anthracycline family, is common anticancer agent often used as first line treatment for wide spectrum cancers. Doxorubicin-based chemotherapy, although effective, associated with serious side effects, such irreversible cardiotoxicity or nephrotoxicity. Those life-threatening adverse risks, responsible elongation patients’ recuperation period and increasing medical expenses, have prompted need creating novel safer drug delivery systems. Among many proposed concepts, polymeric nanocarriers are shown to be promising approach, allowing controlled selective delivery, simultaneously enhancing its activity towards cancerous cells reducing toxic effects on healthy tissues. This article chronological examination history work progress nanostructures, designed efficient doxorubicin nanocarriers, emphasis main achievements 2010–2020. Numerous publications been reviewed provide an essential summation nanopolymer types their properties, mechanisms well active targeting stimuli-responsive strategies that currently utilized in transportation field.