Polymeric Micelles: Morphology, Synthesis, and Pharmaceutical Application

Folate receptor targeted biodegradable polymeric doxorubicin micelles.

Biodegradable polymeric micelles, self-assembled from a di-block copolymer of poly(D,L-lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG), were prepared to achieve folate receptor targeted delivery of doxorubicin (DOX). In the di-block copolymer structure of PLGA-b-PEG, DOX was chemically conjugated to a terminal end of PLGA to produce DOX-PLGA-mPEG, and folate was separately conju...

Microphase separation in binary polymeric micelles

2014 A theoretical analysis of microphase separation in binary micelles is presented. We consider micelles consisting of two kinds of diblock copolymers such that the micellar corona contains two chemically distinct block types (A and B). Both intramicellar and intermicellar processes may occur. We focus on intermicellar segregation occurring after a quench yielding complete intramicellar micro...

Polymeric micelles as drug delivery vehicles

Polymeric micelles drug delivery system in oncology.

Polymeric micelles (PM) system, as an efficient drug carrier, has received growing scientific attention in recent years owing to its solubilization, selective targeting, P-glycoprotein inhibition and altered drug internalization route and subcellular localization properties. Seven PM formulations of anti-tumor drugs being evaluated in clinical trials are reviewed in this paper, in terms of form...

Fluorescence imaging enabled biodegradable photostable polymeric micelles.

Amphiphilic biodegradable photoluminescent polymers (ABPLPs) composed of a biodegradable fluorescent polymer and methoxy poly (ethyleneglycol) demonstrate intrinsic bright, tunable, and stable fluorescence emission. ABPLP micelles elicit minor cellular toxicity and can be used for cell and tissue imaging both in vitro and in vivo.