Polygonatum sibiricum polysaccharide inhibits IL-1β-induced inflammation in human chondrocytes

Osteoarthritis (OA) is a degenerative joint disease associated with inflammation. Polygonatum sibiricum polysaccharide (PSP) major group of active components isolated from broad activities including anti-inflammatory effect. However, the role PSP in OA unclear. In present study, we aimed to investigate effects on IL-1β-induced inflammatory response primary human chondrocytes. The results showed that improved cell viability chondrocytes IL-1β induction. increased levels several mediators nitric oxide (NO), prostaglandin E2 (PGE2), inducible synthase (iNOS) and cyclooxygenase-2 (COX-2) were attenuated by dose-dependent manner. production pro-inflammatory cytokines, TNF-α IL-6, mitigated Besides, also suppressed matrix metalloproteinases (MMPs), MMP-1, MMP-3 MMP-13 IL-1β-stimulated Furthermore, activation NF-κB signaling pathway was prevented PSP. These findings suggested alleviated via inhibiting pathway.