Polycystic Ovaries and Associated Clinical and Biochemical Features in Young Women

Background: The aetiology of polycystic ovarian syndrome (PCOS) is unknown, even though it the most frequent endocrine disorder in women reproductive age. Previous community-based studies were unable to directly estimate prevalence PCOS these communities since they did not conduct comprehensive biochemical and clinical screening. Objective: This research focused on ovaries associated features young women. Study Design: Cross-sectional study Setting: was conducted Department Biochemistry Central Park Medical College, Lahore from 1st August 2022 February 2023. Methodology: During period, volunteers recruited hospitals requested their consent. While informed specifically that scan (ultrasound) would be used detect ovaries. After confirmation ovaries, taken 201 as a case group. To compare data, we also 233 healthy participants control taking consent filling questionnaire both cases controls for hormonal analysis. SPSS version 20 data Results: mean age 25.83 ± 4.6 years 27.12 5.52 with significantly increased BMI PCO compared (p = 0.001). Insulin resistance are those suffering PCO. LH, oestradiol FSH decreased control. level testosterone significant this cohort. SHBG free index different. Practical implication: Even many rural areas experience signs disease, hesitant see gynecologist or endocrinologist treatment due lack disease awareness, management, medical therapy conforms criteria. Most patients don't get because hesitation, which can cause host problems down road. done better understand characteristics ovary Conclusion: infertility Pakistan's leading centers have Women may always symptoms syndrome. However, 26 percent had PCOS. often hyperinsulinemia high levels insulin resistance. LH considerably higher than controls, unrelated. results investigation showed although influence PCO, negative correlation between hormone seen individuals elevated insulin. Hence, management reduce risk Keywords: PCOS, FSH, oestradiole, hyperinsulinemia, HOMA-IR