Polyclonal reconstitution of human marrow after allogeneic bone marrow transplantation

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Polyclonal reconstitution of human marrow after allogeneic bone marrow transplantation.

Clonal dominance suggestive of reconstitution of marrow from small numbers of pluripotent hematopoietic stem cells has been noted in different experimental and clinical situations. Recipients of human allogeneic marrow transplants have not been previously studied to determine if clonal dominance occurs in this clinical setting. Clonal analysis of 20 allogeneic marrow transplant recipients was p...

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Polyclonal reconstitution of human marrow after allogeneic bone marrow

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Interleukin-15 enhances immune reconstitution after allogeneic bone marrow transplantation.

Interleukin-15 (IL-15) is a gamma-common cytokine that plays an important role in the development, survival, and proliferation of natural killer (NK), NK T, and CD8+ T-cells. We administered IL-15 to recipients of an allogeneic bone marrow transplantation (allo BMT) to determine its effects on immune reconstitution. Posttransplantation IL-15 administration significantly increased donor-derived ...

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Allogeneic Bone Marrow Transplantation

A 1 3-yr-old male with acute myelogenous therapy. Then, 53 yr later, he developed leukemia was treated with various chemoan extramedullary relapse with a chlotherapy regimens for 3 yr and then underroma of his maxillary sinus. This case ilwent an allogeneic bone marrow translustrates the need for prolonged followup plantation. The donor marrow was sucof transplant recipients and suggests that c...

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Sir, Vitiligo is a common, depigmenting disorder characterized by well-circumscribed cutaneous macules devoid of melanocytes on the epidermis. Bone marrow transplantation (BMT), which has significant therapeutic benefits in haematologic disorders, such as leukaemia and aplastic anaemia, provides convincing evidence for the role of the immune system in some autoimmune diseases (1). In this repor...

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ژورنال

عنوان ژورنال: Blood

سال: 1988

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v72.6.2031.2031