Polyclonal Immunoglobulin Free Light Chain and Chronic Inflammation
نویسندگان
چکیده
منابع مشابه
Monoclonal vs polyclonal free light chain assays.
Am J Clin Pathol 2009;131:897-903 901 © American Society for Clinical Pathology relative to Freelite (Figure 1). Both patients had negative results for urine BJPs, further undermining the validity of the ELISA assay results. It is possible that the monoclonal antibodies are cross-reacting with the reported IgG λ and IgA λ monoclonal intact immunoglobulins in these patients, leading to falsely r...
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Immunoglobulin free light chains are produced in excess during normal antibody synthesis. Their evaluation is commonly used in case of a monoclonal gammopathy. In polyclonal hypergammaglobulinemia related to the Sjögren syndrome or systemic lupus, erythematosus serum free light chain levels are increased and could correlate with disease activity. We show here that the κ (P < 0.0001) and λ (P = ...
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Immunoglobulin free light chain (FLC) kappa (κ) and lambda (λ) isotypes exist mainly in monomeric and dimeric forms. Under pathological conditions, the level of FLCs as well as the structure of monomeric and dimeric FLCs and their dimerization properties might be significantly altered. The abnormally high fractions of dimeric FLCs were demonstrated in the serum of patients with multiple myeloma...
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ژورنال
عنوان ژورنال: Mayo Clinic Proceedings
سال: 2012
ISSN: 0025-6196
DOI: 10.1016/j.mayocp.2012.07.012