Polyamine Transport by the Polyspecific Organic Cation Transporters OCT1, OCT2, and OCT3
نویسندگان
چکیده
منابع مشابه
The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin.
Organic cation transporters (OCTs) can mediate metformin transmembrane transport. We explored metformin pharmacokinetics in relation to genetic variations in OCT1, OCT2, OCT3, OCTN1, and MATE1 in 103 healthy male Caucasians. Renal clearance varied 3.8-fold and was significantly dependent on creatinine clearance (r(2) = 0.42, P < 0.0001), age (r(2) = 0.09, P = 0.002), and OCT1 polymorphisms. Car...
متن کاملTransport of the dopamine D2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney.
We investigated the mechanism of renal tubular secretion of the dopamine D2 receptor agonist pramipexole in rats, focusing on organic cation transporters 1 and 2. The uptake of [14C]pramipexole by Xenopus oocytes injected with complementary RNA of either rat organic cation transporter (rOCT) 1 or rOCT2 was significantly higher than that by water-injected oocytes: the kinetic parameters, K(m) an...
متن کاملPharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1-3).
For the elimination of environmental toxins and metabolic waste products, the body is equipped with a range of broad-specificity transporters that are generally present in the liver, kidney, and intestine. The polyspecific organic cation transporters OCT1, 2, and 3 (SLC22A1-3) mediate the facilitated transport of a variety of structurally diverse organic cations, including many drugs, toxins, a...
متن کاملLocalization of organic cation transporters OCT1 and OCT2 in rat kidney.
Renal excretion and reabsorption of organic cations are mediated by electrogenic and electroneutral organic cation transporters, which belong to a recently discovered family of polyspecific transporters. These transporters are electrogenic and exhibit differences in substrate specificity. In rat, the renal expression of the polyspecific cation transporters rOCT1 and rOCT2 was investigated. By i...
متن کاملMOLECULAR PHYSIOLOGY IN THE TRANSPORT SYSTEM Proximal Tubular Transport of Organic Compounds Polyspecific cation transporters in the proximal tubule
The homeostasis of endogeneous organic cations, such transported by rOCT1 (unpublished data). OCT1, as choline, monoamine neurotransmitters, nucleosides, OCT2 and OCT3 may also be inhibited by non-charged cationic drugs and cationic xenobiotics, is controlled compounds such as corticosteroids and by anions such by polyspecific cation transporters in small intestine, as probenecid or a-ketogluta...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Pharmaceutics
سال: 2013
ISSN: 1543-8384,1543-8392
DOI: 10.1021/mp400024d