Polarity proteins in oncogenesis
نویسندگان
چکیده
منابع مشابه
Genes Regulating Epithelial Polarity Are Critical Suppressors of Esophageal Oncogenesis
Esophageal cancer is an aggressive disease featured by early lymphatic and hematogenous dissemination, and is the sixth leading cause of cancer-related deaths worldwide. The proper formation of apicobasal polarity is essential for normal epithelium physiology and tissue homeostasis, while loss of polarity is a hallmark of cancer development including esophageal oncogenesis. In this review, we s...
متن کاملThe low polarity of many membrane proteins.
The polarities of a large number of soluble and membrane proteins have been calculated by summing the mole fractions of polar amino acids. It was found that 85% of the 205 soluble proteins considered in this study had polarities of 47 +/- 6%. Only 2% of the soluble proteins had polarities below 40%, whereas 47% of the 19 membrane proteins had polarities below 40%. The membrane proteins with pol...
متن کاملElaborating polarity: PAR proteins and the cytoskeleton.
Cell polarity is essential for cells to divide asymmetrically, form spatially restricted subcellular structures and participate in three-dimensional multicellular organization. PAR proteins are conserved polarity regulators that function by generating cortical landmarks that establish dynamic asymmetries in the distribution of effector proteins. Here, we review recent findings on the role of PA...
متن کاملCell polarity: Scaffold proteins par excellence
Par proteins are involved in determining cellular asymmetry. Recent studies have identified one of these proteins, Par6, as a key regulator of cell polarity and transformation via its interactions with small GTPases and atypical forms of protein kinase C.
متن کاملCiliogenesis: Polarity Proteins on the Move
The formation and maintenance of cilia and flagella require a selective and directed transport along the axoneme, a characteristic central bundle of microtubules. Recent evidence suggests an interesting link between the generation of cilia and the protein complexes that establish apico-basal cell polarity.
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ژورنال
عنوان ژورنال: Current Opinion in Cell Biology
سال: 2020
ISSN: 0955-0674
DOI: 10.1016/j.ceb.2019.07.016