Podosome-type adhesions and focal adhesions, so alike yet so different
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چکیده
منابع مشابه
Podosome-type adhesions and focal adhesions, so alike yet so different.
Cell-matrix adhesions are essential for cell migration, tissue organization and differentiation, therefore playing central roles in embryonic development, remodeling and homeostasis of tissues and organs. Matrix adhesion-dependent signals cooperate with other pathways to regulate biological functions such as cell survival, cell proliferation, wound healing, and tumorigenesis. Cell migration and...
متن کاملFocal adhesions
What are they? Focal adhesions are the anchor points of the cell. These dynamic cytoskeletal structures are regions where the cell membrane firmly attaches to the extracellular matrix or the substratum. At the same time, focal adhesions provide scaffolding; they associate with an elaborate actin network inside the cell. Importantly, it’s now known that focal adhesions also act as communication ...
متن کاملMechanotransduction and focal adhesions.
Cellular FAs (focal adhesions) respond to internal and external mechanical stresses which make them prime candidates for mechanotransduction. Recent observations showed that the FA proteins including vinculin, FAK (FA kinase) and p130Cas are crucial for the ability of cells to transmit forces and to generate cytoskeletal tension. When mechanically stimulated, cells respond by modulating the spr...
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Vibrios are natural inhabitants of aquatic environments and form symbiotic or pathogenic relationships with eukaryotic hosts. Recent studies reveal that the ability of vibrios to form biofilms (i.e. matrix-enclosed, surface-associated communities) depends upon specific structural genes (flagella, pili and exopolysaccharide biosynthesis) and regulatory processes (two-component regulators, quorum...
متن کاملFocal adhesions come unstuck
Focal adhesions come unstuck C rawling cells pick up after themselves before moving on. Ezratty et al. (1) show that cells use the endocytic protein clathrin to reabsorb the integrin receptors that attach them to surfaces, instead of simply leaving the molecules behind. Cells on the go gain traction by forming focal adhesions (FAs), temporary attachments to the surface. But if they can't break ...
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ژورنال
عنوان ژورنال: European Journal of Cell Biology
سال: 2008
ISSN: 0171-9335
DOI: 10.1016/j.ejcb.2008.02.012