Podophyllotoxin and 6-methoxy podophyllotoxin Production in Hairy Root Cultures of Liunm mucronatum ssp. mucronatum
نویسندگان
چکیده
منابع مشابه
Root cultures of linum species section Syllinum as rich sources of 6-methoxypodophyllotoxin.
Linum spp. from section Syllinum are promising for the production of aryltetralin lignans like podophyllotoxin (PTOX) and 6-methoxypodophyllotoxin (MPTOX). MPTOX is a PTOX congener that has cytotoxic activity comparable with PTOX. In this study root cultures of Linum Bungei from section Dasyllinum, L. strictum from section Linastrum, L. album, L. mucronatum ssp. mucronatum and L. nodiflorum fro...
متن کاملImprovement of lignans production in hairy root culture of Linum mucronatum using abiotic and biotic elicitors .
Elicitors could be used as the enhancer of plant secondary-metabolite synthesis and could play an important role in biosynthetic pathways of important medicinal compounds. The present study investigated the effect of abiotic elicitor (fungal extract of Fusarium graminearum) and two abiotic elicitors (methyl jasmonate and salicylic acid) at different concentrations in 18- and 30-day-old cultures...
متن کاملRoot cultures of Linum spp. (section Syllinum) as a source of 6-methoxypodopyllotoxin
Linum spp. (Linaceae) has been shown to accumulate cytotoxic lignans such as podophyllotoxin and 6-methoxypodopyllotoxin. Therefore, plant cell and tissue cultures of Linum spp. may be possible alternative sources for the lignan production. In this study, we focused on the production of lignans by root cultures of Linum spp. Hairy root cultures of L. nodiflorum, L.album and L. austriacum and ro...
متن کاملRoot cultures of Linum spp. (section Syllinum) as a source of 6-methoxypodopyllotoxin
Linum spp. (Linaceae) has been shown to accumulate cytotoxic lignans such as podophyllotoxin and 6-methoxypodopyllotoxin. Therefore, plant cell and tissue cultures of Linum spp. may be possible alternative sources for the lignan production. In this study, we focused on the production of lignans by root cultures of Linum spp. Hairy root cultures of L. nodiflorum, L.album and L. austriacum and ro...
متن کاملAccumulation of lignans in suspension cultures of Linum mucronatum ssp. armenum (Bordz.) Davis.
For the first time callus and suspension cultures of Linum mucronatum ssp. annenum were initiated, grown in darkness at 25 degrees C and analyzed for lignans. 6-Methoxypodophyllotoxin was the main lignan besides smaller amounts of podophyllotoxin isolated and identified by chromatographic methods as well as by 1H NMR.
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ژورنال
عنوان ژورنال: Pharmacognosy Magazine
سال: 2014
ISSN: 0973-1296
DOI: 10.4103/0973-1296.131027