PO-01-153 HIGHER PREVALENCE OF CLONAL HEMATOPOIESIS OF INDETERMINATE POTENTIAL IN ATRIAL FIBRILLATION

Both clonal hematopoiesis of indeterminate potential (CHIP) and atrial fibrillation (AF) are age-related conditions. CHIP is associated with increased cardiovascular disease risk, contributing to AF development. However, the association between unknown. To investigate prevalence mutations in patients their clinical characteristics differentiated by CHIP. Deep-targeted sequencing 24 was performed compared 690 3,341 non-AF healthy adults. Variant allele fraction (VAF) ≥2.0% indicated presence. The baseline cohort were as follows: mean age, 67.5±6.7 years; male, 474 (68.7%); persistent AF, 316 (45.8%) cases. Twenty-four a VAF at least 0.02 found 160 (23.3%) 356 (10.7%) adults (p<0.001). most commonly occurring somatic mutation genes DNMT3A (13.5%), TET2 (7.0%), ASXL1 (1.7%). After multivariable adjustment, 1.3-fold higher than adults: odds ratio (OR), 1.34 95% confidence interval (CI), 1.04-1.73, p=0.026. In gene-specific analyses, presented highest (OR, 1.71; CI, 1.05–2.81, p=0.033). showed older more diabetes, longer duration, severely enlarged left atrium, E/E’ those without mutations. mutations, primarily or TET2, 1.3–1.7-fold prevalent related progressed AF. Further studies required understand genetic architecture