Pneumococcal pathogenesis: “innate invasion” yet organ-specific damage

Molecular pathogenesis of pneumococcal pneumonia.

The past two decades have witnessed an explosion of data on the molecular pathogenesis of pneumonia caused by Streptococcus pneumoniae, one of the most important pathogens currently plaguing man. Identification and functional analysis of genes and their proteins, elucidation of mechanisms involved in adherence, colonization, inflammation, and invasion, and an understanding of interactions with ...

Specific, Yet Opaque

In her dissertation, Janet Fodor has argued that the quantificational force and the intensional status of certain quantifier phrases can be evaluated independently. The proposal was only halfway accepted: the existence of non-specific transparent readings is well-established today, but specific opaque readings are deemed illusory. I argue that they are real and outline a semantic framework that...

Receptor and TLR Stimulation and Damage by Nephrotoxic Antibodies via Fc Innate Stimuli Accentuate End-Organ

Multiple Organ Damage Due to Boric Acid Toxicity

Background: Boric acid (BA) is commonly used as pesticide, disinfectant and wood preservative. Its ingestion can cause serious organ damages resulting in death. Case report: A 19 year old man was found dead with two empty packs of BA tablets in vicinity of his body. On autopsy examination, brownish stains along with right angle of mouth and right nostril were found. Stomach was damaged with hem...

Tissue Specific Expression of Human Calcitonin Gene in Potato Tubers by an Organ Specific Promoter

To increase the production level of heterologous proteins in plants, strategies such as choice of strongerpromoters, optimization of codon usage and specific localization of foreign proteins are of major concern.Calcitonin (CT), a 32 amino acid polypeptide is a powerful and specific inhibitor of bone resorption and isused to treat several human diseases. Calcitonin activity is...