Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity
نویسندگان
چکیده
منابع مشابه
Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity.
We have previously shown that radiation increases HIF-1 activity in tumors, causing significant radioprotection of the tumor vasculature. The impact that HIF-1 activation has on overall tumor radiosensitivity, however, is unknown. We reveal here that HIF-1 plays an important role in determining tumor radioresponsiveness through regulating four distinct processes. By promoting ATP metabolism, pr...
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ژورنال
عنوان ژورنال: Cancer Cell
سال: 2005
ISSN: 1535-6108
DOI: 10.1016/j.ccr.2005.06.016