Platelet Coagulant Activities and Hemostasis: A Hypothesis
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چکیده
منابع مشابه
Platelet coagulant activities and hemostasis: a hypothesis.
Platelets have recently been shown to participate in reactions with blood coagulation factors at every stage of intrinsic clotting, from contact activation to fibrin formation. Platelets can trigger intrinsic coagulation by two alternative pathways, the first of which involves factors XII and Xl and adenosine diphosphate, and the second of which bypasses factor XII, provided factor Xl and colla...
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Ischemic optic neuropathy and retinal arterial occlusion are 2 forms of arterial occlusive disease affecting the eye. Reports in the literature suggest platelet hyperactivity in acute arterial occlusive diseases affecting other organ systems. Therefore, 14 patients with ischemic optic neuropathy and 17 patients with central or branch retinal artery occlusion were studied to determine whether pl...
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Traditionally, platelets have been thought of as anuclear, subcellular fragments derived from megakaryocytes circulating in blood as small discs and mitigating hemorrhage. This hemostatic process requires platelet activation, a complex chain of events involving rapid structural changes that activate adhesion receptors, remodel the cytoskeleton, and lead to the eventual synthesis and secretion o...
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Platelets represent the main effectors in the formation of the initial hemostatic plug through an elaborate response to vascular injury, and furthermore, platelets play an essential role in secondary hemostasis.1 However, platelets are also important contributors to pathological thrombus formation and vessel occlusion when activated inappropriately. Moreover, platelets contribute to processes b...
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ژورنال
عنوان ژورنال: Blood
سال: 1974
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v43.4.597.597