Platelet and Blood Vessel Arachidonate Metabolism and Interactions
نویسندگان
چکیده
منابع مشابه
Systems biology of platelet-vessel wall interactions
Blood systems biology seeks to quantify outside-in signaling as platelets respond to numerous external stimuli, typically under flow conditions. Platelets can activate via GPVI collagen receptor and numerous G-protein coupled receptors (GPCRs) responsive to ADP, thromboxane, thrombin, and prostacyclin. A bottom-up ODE approach allowed prediction of platelet calcium and phosphoinositides followi...
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During the prolonged course of atherosclerotic disease, platelets are of central importance as they contribute to the initiation of the disease, to its progression and acute exacerbation but also provide potential regenerative mechanisms. Platelets secrete chemokines and cytokines that mediate vascular inflammation and are in turn activated by substances released from cells of the vascular wall...
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The process of platelet thrombus formation contributes to the haemostatic response that prevents excessive blood loss after tissue injury, but may become a life-threatening disease mechanism by causing the acute thrombotic occlusion of atherosclerotic arteries. The participation of platelets in the formation of thrombi is centered on their adhesive properties and the ability to respond to stimu...
متن کاملAbnormal platelet function and arachidonate metabolism in chronic idiopathic thrombocytopenic purpura.
We observed several patients with chronic idiopathic thrombocytopenic purpura (ITP) whose bleeding times were more prolonged than would have been expected from their platelet counts. To investigate this further, we performed in vivo and in vitro platelet function studies, assessed arachidonate metabolism, and measured platelet-associated IgG (PAIGG) in seven patients with chronic ITP. The bleed...
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T relationship among platelet survival, vessel injury, and thrombosis is of interest because of the role that platelets play in the development of atherosclerosis and its thromboembolic complications. Blood platelets do not adhere to normal endothelium. However, when a blood vessel is injured, platelets adhere to the injury site and, if blood flow is disturbed, thrombi can form on the injured a...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1979
ISSN: 0021-9738
DOI: 10.1172/jci109309