Plasticity of Addiction: A Mesolimbic Dopamine Short-Circuit?
نویسندگان
چکیده
منابع مشابه
Neuroplasticity in the mesolimbic dopamine system and cocaine addiction.
The main characteristics of cocaine addiction are compulsive drug use despite adverse consequences and high rates of relapse during periods of abstinence. A current popular hypothesis is that compulsive cocaine use and cocaine relapse is due to drug-induced neuroadaptations in reward-related learning and memory processes, which cause hypersensitivity to cocaine-associated cues, impulsive decisi...
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The factors causing the transition from recreational drug consumption to addiction remain largely unknown. It has not been tested whether dopamine (DA) is sufficient to trigger this process. Here we use optogenetic self-stimulation of DA neurons of the ventral tegmental area (VTA) to selectively mimic the defining commonality of addictive drugs. All mice readily acquired self-stimulation. After...
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The mesolimbic dopamine system comprises neurons in the ventral tegmental area (VTA) andsubstantia nigra (SN), projecting to the ventral striatum. This system was originally described to mediate pleasure and goal-directed movement associated with rewarding stimuli. However, it is now clear that dopamine, although crucial for reward processing, drives not the hedonic experience of reward (“likin...
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Nucleus accumbens dopamine is known to play a role in motivational processes, and dysfunctions of mesolimbic dopamine may contribute to motivational symptoms of depression and other disorders, as well as features of substance abuse. Although it has become traditional to label dopamine neurons as "reward" neurons, this is an overgeneralization, and it is important to distinguish between aspects ...
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Nicotine exerts its reinforcing action by stimulating nicotinic acetylcholine receptors (nAChRs) and boosting dopamine (DA) output from the ventral tegmental area (VTA). Recent data have led to a debate about the principal pathway of nicotine action: direct stimulation of the DAergic cells through nAChR activation, or disinhibition mediated through desensitization of nAChRs on GABAergic interne...
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ژورنال
عنوان ژورنال: American Journal on Addictions
سال: 2009
ISSN: 1055-0496,1521-0391
DOI: 10.1080/10550490902925946