منابع مشابه
Plasma cholinesterase and malignant hyperthermia.
Sir,—Humphrey, Downing and Brock-Utne (1980) are less than accurate in describing the destiny of expiration switched to inspiration in the Johannesburg Circuit. They vaguely refer to experimental evidence gathered "while studying a similar system"—evidence which simply does not tally with known pharmacokinetic principles. With a fresh gas inflow of 70mlkg~' min"' in a patient weighing 65 kg, th...
متن کاملA new high activity plasma cholinesterase variant.
A South African Afrikaans speaking family is reported in which a new high activity plasma cholinesterase variant was found to occur in the mother and son. The variant has the same electrophoretic mobility as the "usual' enzyme, but greater heat stability. Its higher specific activity is associated with a normal number of enzyme molecules. The variant may be inherited as a dominant trait, though...
متن کاملInfluence of ketamine on human plasma cholinesterase.
The influence of ketamine upon human plasma cholinesterase (E.C. 3.1.1.8) was determined by means of a colorimetric assay technique at 25 degrees C, pH 7.7 with butyrylthiocholine as substrate. Ketamine caused a reversible inhibition of cholinesterase (pI50= 2.75; apparent Ki=4.94X10(-4) M). The kinetic analysis of the inhibitory action revealed a mixed competitive/non-competitive type of mecha...
متن کاملPlasma cholinesterase deficiency in a neonate.
We report a two-day-old infant who had a period of apnoea lasting six hours following the intravenous administration of succinylcholine (Sch). The results of her plasma cholinesterase level and dibucaine number indicate a congenital absence of plasma cholinesterase (PChE) enzyme, although both parents and siblings had normal cholinesterase levels and dibucaine numbers. This is believed to be th...
متن کاملPlasma Cholinesterase Activity in Alzheimer's Disease.
Cholinesterase inhibitors (ChEIs) are not allowed to be prescribed in combination, which means that we need to select 1 of 3 ChEIs for use in a patient with Alzheimer's disease (AD). However, there is no quantitative analysis on the differences between these agents. In this article, we propose that plasma cholinesterase activity (pChE) could be used as the standard for differentiating between r...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1978
ISSN: 0007-0912
DOI: 10.1093/bja/50.9.945