Plasma Surface Engineering to Biofunctionalise Polymers for ?-Cell Adhesion
نویسندگان
چکیده
Implant devices containing insulin-secreting ?-cells hold great promise for the treatment of diabetes. Using in vitro cell culture, long-term function and viability are enhanced when cultured with extracellular matrix (ECM) proteins. Here, our goal is to engineer a favorable environment within implant devices, where ECM proteins stably immobilized on polymer scaffolds, better support ?-cell adhesion. Four different candidates (low-density polyethylene (LDPE), polystyrene (PS), polyethersulfone (PES) polysulfone (PSU)) were treated using plasma immersion ion implantation (PIII) enable covalent attachment laminin their surfaces. Surface characterisation analysis shows increased hydrophilicity, polar groups radical density all polymers after treatment. Among four polymers, PIII-treated LDPE has highest water contact angle lowest which correlate well non-significant protein binding improvement observed 2 months storage. The study found that created by PIII aromatic was higher than aliphatic polymers. significantly improves making them substrates
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ژورنال
عنوان ژورنال: Coatings
سال: 2021
ISSN: ['2079-6412']
DOI: https://doi.org/10.3390/coatings11091085