Plasma Membrane Furrows Control Plasticity of ER-PM Contacts
نویسندگان
چکیده
منابع مشابه
Plasma membrane-cell wall contacts.
In the simplest sense, cell walls are a carbohydrate and protein structures that surround and separate cells. Perhaps the most familiar cell wall structures are cork and wood, where the cell wall remains after the cells within have degraded. Cotton, the fiber that keeps some of us clothed in our complex world, is also a type of cell wall. These are specialized examples, and it is clear that liv...
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The cortical endoplasmic reticulum (ER), an elaborate network of tubules and cisternae [1], establishes contact sites with the plasma membrane (PM) through tethering machinery involving a set of conserved integral ER proteins [2]. The physiological consequences of forming ER-PM contacts are not fully understood. Here, we reveal a kinetic restriction role of ER-PM contacts over ring compaction p...
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Junctions that connect the endoplasmic reticulum (ER) and the plasma membrane (PM) are unique yet ubiquitous subcellular compartments. Giordano et al. now report that extended synaptotagmins (E-Syts) promote their formation, providing fundamental insight into the molecular machinery controlling ER and plasma membrane crosstalk.
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Plasma membrane PI4P is an important direct regulator of many processes that occur at the plasma membrane and also a biosynthetic precursor of PI(4,5)P2 and its downstream metabolites. The majority of this PI4P pool is synthesized by an evolutionarily conserved complex, which has as its core the PI 4-kinase PI4KIIIa (Stt4 in yeast) and also comprises TTC7 (Ypp1 in yeast) and the peripheral plas...
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Plasma membrane PI4P is an important direct regulator of many processes that occur at the plasma membrane and also a biosynthetic precursor of PI(4,5)P2 and its downstream metabolites. The majority of this PI4P pool is synthesized by an evolutionarily conserved complex, which has as its core the PI 4-kinase PI4KIIIα (Stt4 in yeast) and also comprises TTC7 (Ypp1 in yeast) and the peripheral plas...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2020
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2019.12.098