منابع مشابه
Nature of functional estrogen receptors at the plasma membrane.
Although rapid signaling by estrogen at the plasma membrane is established, it is controversial as to the nature of the receptor protein. Estrogen may bind membrane proteins comparable to classical nuclear estrogen receptors (ERs), but some studies identify nonclassical receptors, such as G protein-coupled receptor (GPR)30. We took several approaches to define membrane-localized estrogen-bindin...
متن کاملPlasma membrane estrogen receptors exist and functions as dimers.
A small pool of estrogen receptors (ERalpha and -beta) localize at the plasma membrane and rapidly signal to affect cellular physiology. Although nuclear ERs function mainly as homodimers, it is unknown whether membrane-localized ER exists or functions with similar requirements. We report that the endogenous ER isoforms at the plasma membrane of breast cancer or endothelial cells exist predomin...
متن کاملFunctional roles of plasma membrane localized estrogen receptors.
A series of emerging data supports the existence and importance of plasma membrane localized estrogen receptors in a variety of cells that are targets for the steroid hormone action. When estradiol (E2) binds to the cell surface protein, the ensuing signal transduction event triggers downstream signaling cascades that contribute to important biological functions. Aside from the classical signal...
متن کاملPlasma membrane receptors.
Receptors are macromolecules in or on cells that mediate physiological responses upon binding specific li-gands. Over the past few years, important advances have been made in the understanding of the biology of receptors, both at a basic and at a clinical level. Receptors bind their ligands with remarkable selectiv-ity and with high affinity, permitting a given physiological response to be elic...
متن کاملPlasma membrane IP3 receptors.
IP3Rs (inositol 1,4,5-trisphosphate receptors) are expressed in the membranes of non-mitochondrial organelles in most animal cells, but their presence and role within the plasma membrane are unclear. Whole-cell patch-clamp recording from DT40 cells expressing native or mutated IP3Rs has established that each cell expresses just two or three functional IP3Rs in its plasma membrane. Only approx. ...
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ژورنال
عنوان ژورنال: Trends in Endocrinology & Metabolism
سال: 2009
ISSN: 1043-2760
DOI: 10.1016/j.tem.2009.06.009