Plasma Ghrelin Concentration and Energy Balance: Overfeeding and Negative Energy Balance Studies in Twins
نویسندگان
چکیده
منابع مشابه
Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin.
BACKGROUND/AIMS The gastric peptide ghrelin, an endogenous ligand for growth-hormone secretagogue receptor, has two major molecular forms: acylated ghrelin and desacyl ghrelin. Acylated ghrelin induces a positive energy balance, while desacyl ghrelin has been reported to be devoid of any endocrine activities. The authors examined the effects of desacyl ghrelin on energy balance. METHODS The a...
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Ghrelin, the endogenous ligand of the GH secretagogue receptor, has a pleiotropic role in the modulation of energy balance. Recent evidence has demonstrated that besides its orexigenic role, ghrelin regulates central and peripheral lipid metabolism through specific control of hypothalamic AMP-activated protein kinase (AMPK), a critical metabolic gauge regulating both cellular and whole-body ene...
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Ghrelin, the first identified endogenous ligand for the growth hormone secretagogue receptor 1A, is a 28 amino acid peptide produced mainly by the stomach. Pharmacological studies indicate a role for ghrelin in the regulation of growth hormone secretion from the pituitary and also in the regulation of body weight, fat accumulation and food intake. Using a classical endocrine deletion/replacemen...
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Ghrelin is a gut peptide composed of 28 amino acids mostly secreted in the gastric fundus mucosa. It was isolated and described in 1999 by Kojima et al. and only three years later its specific receptor, GHSR1a, was also identified. Ghrelin, the endogenous ligand for the GH secretagogue receptor, is the only peripheral orexigenic hormone that activates the receptors to be found especially in the...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2001
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jcem.86.9.8003