Plasma-Free Fatty Acids, Fatty Acid–Binding Protein 4, and Mortality in Older Adults (from the Cardiovascular Health Study)
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چکیده
منابع مشابه
Plasma Fatty Acid–Binding Protein 4, Nonesterified Fatty Acids, and Incident Diabetes in Older Adults
OBJECTIVE To examine the relation of fatty acid-binding protein (FABP)4 and nonesterified fatty acids (NEFAs) to diabetes in older adults. RESEARCH DESIGN AND METHODS We ascertained incident diabetes among 3,740 Cardiovascular Health Study participants (1992-2007) based on the use of hypoglycemic medications, fasting glucose ≥ 126 mg/dL, or nonfasting glucose ≥ 200 mg/dL. FABP4 and NEFA were ...
متن کاملPlasma Phospholipid Trans‐Fatty Acids Levels, Cardiovascular Diseases, and Total Mortality: The Cardiovascular Health Study
BACKGROUND While self-reported trans-fatty acid (TFA) consumption is linked to coronary heart disease (CHD), relationships between objective biomarkers of TFA subtypes (t-16:1n9, total t-18:1, and cis/trans-(c/t-), t/c- and t/t-18:2) and cardiovascular disease (CVD) or total mortality are not well established. METHODS AND RESULTS We evaluated 2742 adults in the Cardiovascular Health Study, ag...
متن کاملPlasma phospholipid trans fatty acids, fatal ischemic heart disease, and sudden cardiac death in older adults: the cardiovascular health study.
BACKGROUND Intake of trans fatty acids is associated with increased risk of coronary heart disease. Whether different classes of trans fatty acids show similar associations is unclear. We previously reported an association of sudden cardiac death with red cell membrane trans-18:2 but not trans-18:1 fatty acids. To extend these findings, we investigated the associations of plasma phospholipid tr...
متن کاملPlasma free fatty acids and risk of heart failure: the Cardiovascular Health Study.
BACKGROUND Although plasma free fatty acid (FFA) concentrations have been associated with lipotoxicity, apoptosis, and risk of diabetes mellitus and coronary heart disease, it is unclear whether FFA levels are associated with heart failure (HF). METHODS AND RESULTS To test the hypothesis that plasma concentration of FFAs is positively associated with incident HF, we prospectively analyzed dat...
متن کاملFree fatty acids, cardiovascular mortality, and cardiometabolic stress.
Free fatty acids (FFAs) are non-esterified fatty acids that circulate in the bloodstream predominantly bound to albumin. FFAs are released from adipocyte triglyceride stores by lipolysis and from phospholipids by the action of phospholipases. Release of FFAs, as well as uptake of circulating FFAs by tissues such as skeletal muscle and liver, is regulated by the action of insulin and modulated b...
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ژورنال
عنوان ژورنال: The American Journal of Cardiology
سال: 2014
ISSN: 0002-9149
DOI: 10.1016/j.amjcard.2014.06.012