Plasma exchange v peritoneal dialysis for removing Bence Jones protein.

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What's in a name? Bence Jones protein

Plasma cell disorders are important in the differential diagnosis of acute kidney injury and of renal impairment with proteinuria. One or more of several mechanisms can be involved, such as cast nephropathy, deposition of monoclonal immunoglobulins, formation of amyloid fibrils, hypercalcaemia, hyperuricaemia and a variety of tubular syndromes. Various tests, such as serum electrophoresis and i...

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The Fate of Injected Bence Jones Protein

Bence Jones protein injected into rabbits was excreted rapidly into the urine. The excreted protein retained the physicochemical and immunochemical properties of the injected Bence Jones protein. In spite of the rapid excretion, a significant portion of the injected Bence Jones protein was found to be metabolized. After reinjection of radioactive Bence Jones protein into the donor patient, only...

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Bence Jones protein in primary systemic amyloidosis.

The recent population-based study by Kyle et al,’ which was the first to provide precise epidemiologic information about primary systemic amyloidosis, reported the demonstration of a monoclonal (M)protein in the serum or urine from 16 of 21 patients (76%) with amyloid of unequivocal Ig origin (AL). However, the number of patients in whom free monoclonal Ig light chain (ie, Bence Jones [BJ] prot...

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Bence Jones myeloma with signet-ring-like plasma cells.

Signet-ring cells, typical of muciparous adenocarcinoma, are seldom observed in other solid tumors or in lymphoproliferative disorders. Two cases of myeloma with signet-ring morphology have been reported so far. To the best of our knowledge, the following is the first case of signetring cell Bence-Jones myeloma. A 69-year-old man presented with cachexy, dehydration, liver enlargement and multin...

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Intranuclear inclusions in Bence Jones lambda plasma cell myeloma.

A patient with plasma cell myeloma producing only Bence Jones lambda protein was found to have pale intranuclear inclusions in the majority of the bone marrow plasma cells. These inclusions, previously undescribed in myeloma patients producing only Bence Jones protein, contained Bence Jones lambda protein, were non-electron dense, bound by a single membrane, and contained no cytoplasmic structu...

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ژورنال

عنوان ژورنال: BMJ

سال: 1978

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.2.6149.1397