Plasma concentrations and coronary vasodilation after sublingual and intracoronary administration of isosorbide dinitrate
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منابع مشابه
Coronary dilating effects of intracoronary nicorandil. Comparison with isosorbide dinitrate.
Although nicorandil, N-(2-hydroxyethyl) nicotinamide dinitrate, is a nitrate ester, its cardiovascular action differs from that of nitrate compounds in several aspects. In this quantitative angiographic study, the acute coronary dilating effect of intracoronary nicorandil (0.25, 0.50, 1.0 mg) was compared with that of isosorbide dinitrate (ISDN; 1.0 mg) in 46 patients with or without ischemic h...
متن کاملSublingual isosorbide dinitrate therapy versus sublingual acebo in angina pectoris.
A double-blind crossover study comparing the effects of 5 mg of isosorbide dinitrate given sublingually four times daily for 4 weeks to those of a placebo also administered sublingually four times daily for 4 weeks was performed on 20 male patients with classical exeitional angina pectoris due to coronary artery disease. Isosorbide dinitrate, compared to placebo, significantly reduced the numbe...
متن کاملDilation of coronary artery stenoses after isosorbide dinitrate in man.
The effect of isosorbide dinitrate (ISDN), 5 mg sublingually, on the diameters of coronary artery stenoses (n = 27) was examined in 20 patients. Another 18 patients with angiographically normal coronary arteries received the same amount of ISDN and were used as controls. Prestenotic and stenotic diameters were measured with a vernier calliper having an accuracy of 0.05 mm. The degree of stenosi...
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BACKGROUND New indications for misoprostol include medical abortion, cervical softening, induction of labor and treatment of postpartum hemorrhage. Various routes of misoprostol administration under study include oral, vaginal, buccal, sublingual and rectal. MATERIALS AND METHODS This was an open-label, randomized, cross-over study of the pharmacokinetic differences of buccal vs. sublingual m...
متن کاملImpact of Timing and Dose of Isosorbide dinitrate Administration on Coronary MRI
Introduction Despite technical progress, coronary magnetic resonance imaging (MRI) still faces multiple challenges including low SNR and small vessel size. Coronary vasodilators, such as sublingual nitroglycerin (NTG) or longer acting nitrates (e.g., isosorbide dinitrate), are commonly used to study coronary circulation. Terashima et al. [1] reported on the impact of sublingual NTG on coronary ...
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ژورنال
عنوان ژورنال: Clinical Cardiology
سال: 1995
ISSN: 0160-9289,1932-8737
DOI: 10.1002/clc.4960181110