منابع مشابه
Stathmin 1 expression in plasma cell neoplasms
Multiple myeloma (MM) is a hematological malignancy characterized by clonal proliferation of malignant plasma cells which accumulate in the bone marrow, resulting in recurrent hypercalcemia, anemia, osteolytic lesions, renal failure, and increased risk of infection.1 Stathmin 1, also named oncoprotein 18 (OP18) or leukemia-associated phosphoprotein p18 (LAP18), is a microtubule destabilizer tha...
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INTRODUCTION Pancreatic involvement by plasma cell neoplasms is an extremely rare event, with only 50 cases described in the literature. They can present as a primary solitary extramedullary plasmacytoma or plasmacytoma secondary to a plasma cell myeloma. Clinical manifestations are due to the presence of a pancreatic mass usually in the pancreas head, which causes extra-biliary obstruction and...
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The application of immunohistology to the spectrum of plasma cell disorders has yet to be incorporated widely into routine haematology practice. This technique enables the direct visualisation of specific surface and cytoplasmic antigens in the context of the individual cell and the surrounding anatomical neighbourhood. This review outlines the role of bone marrow immunohistology in the laborat...
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Session 1 of the 2009 Workshop of the Society for Hematopathology/European Association of Haematopathology, Cleveland, OH, focused on plasma cell neoplasms. This report summarizes the salient diagnostic, clinical, and genetic features of plasma cell myeloma (PCM) and related neoplasms. Based on the cases submitted to the workshop, we highlight common diagnostic issues and unusual manifestations...
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Plasma cell neoplasms are phenotypically heterogeneous disorder with broad spectrum, including plasma cell myeloma, monoclonal gammopathy of unknown significance, and amyloidosis. Each plasma cell neoplasm is defined by diagnostic criteria and, accordingly, therapeutic strategies are developed. Scientists often have difficulties in discovering genetics of plasma cell neoplasms due to problem of...
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ژورنال
عنوان ژورنال: CA: A Cancer Journal for Clinicians
سال: 1976
ISSN: 0007-9235
DOI: 10.3322/canjclin.26.1.38