Plasma cell leukemia masquerading as lymphoplasmacytic lymphoma: a diagnostic challenge
نویسندگان
چکیده
منابع مشابه
Concomitant lymphoplasmacytic lymphoma and plasma cell myeloma, a diagnostic challenge.
BACKGROUND Lymphoplasmacytic lymphoma and plasma cell myeloma are two B cell lymphoproliferative neoplasms derived from mature B-lymphocytes in different differentiation stages. The coexistence of these two tumors in the same patient is exceedingly rare and can be difficult to diagnose. CASE PRESENTATION A 76-year-old male presented with a pathologic fracture after a fall. Radiography showed ...
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Plasma cell leukemia (PCL) is a rare and aggressive manifestation of malignant plasma cell proliferation and corresponds to 2–4% of multiple myeloma (MM) cases.1,2 The World Health Organization (WHO) defines PCL by the presence of high levels (at least 2 × 109/L) of clonal plasma cells in the peripheral blood (PB) or at least 20% of the leukocyte differential count.1 Primary PCL (pPCL) correspo...
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A 55-year-old man was admitted with fever and rapidly progressive renal failure with serum creatinine levels of 6.5 mg/dL and blood urea of 98 mg/dL. Complete blood counts revealed a hemoglobin of 50 g/L, a leukocyte count of 13.3 3 10/L, and a platelet count of 46 3 10/L. Peripheral blood smear examination showed clusters of cells dispersed throughout the smear (panels A-D). These clusters wer...
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Survival of patients with multiple myeloma has improved substantially because of availability of new therapies including autotransplants, immunomodulating drugs and proteasome-inhibitors. Second primary cancers have emerged as an important determinant of morbidity and mortality among cancer survivors. Even though there is an increased risk of new cancers of the lymphoreticular and haematopoetic...
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ژورنال
عنوان ژورنال: Journal of Hematopathology
سال: 2019
ISSN: 1868-9256,1865-5785
DOI: 10.1007/s12308-019-00343-1