Plasma Angiotensin I Converting Enzyme Activity in Rabbits under Various Experimental Conditions

Angiotensin Converting Enzyme in Sarcoidosis

Angiotensin I converting enzyme.

• Interest in particular biologically active substances waxes and wanes. Investigators rush into a newly opened field, solve a few problems, and frequently raise more; then they rush out to follow more promising developments elsewhere. However, interest in angiotensins generally has persisted and increased. Observation of the actions of angiotensins has led to the study of enzymes involved in t...

Nitric oxide regulates angiotensin-I converting enzyme under static conditions but not under shear stress.

Mechanical forces including pressure and shear stress play an important role in vascular homeostasis via the control of the production and release of a variety of vasoactive factors. An increase in vascular shear stress is accompanied by nitric oxide (NO) release and NO synthase activation. Previously, we have demonstrated that shear stress induces angiotensin-I converting enzyme (ACE) down-reg...

Two loci affect angiotensin I-converting enzyme activity in baboons.

Serum LDL cholesterol (LDLC) concentrations and ACE activities are risk factors for the development of cardiovascular disease (CVD). However, the relationship between ACE and CVD susceptibility, and possible mechanisms of action, is controversial. With data on 622 pedigreed baboons, we used statistical genetic methods to determine the mode of inheritance of ACE activities and its relationship t...

Plasma angiotensin-converting enzyme activity and carotid wall thickening.

BACKGROUND Mechanisms underlying the previously reported association between a deletion polymorphism in the gene encoding for angiotensin-converting enzyme (ACE) and the risk of myocardial infarction in low-risk subjects are unclear. The purpose of this case-control study was to examine the relation of plasma ACE activity to intimal-medial thickness of the carotid wall measured ultrasonographic...