Plant d-2-Hydroxyglutarate Dehydrogenase Participates in the Catabolism of Lysine Especially during Senescence

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Plant D-2-hydroxyglutarate dehydrogenase participates in the catabolism of lysine especially during senescence.

D-2-Hydroxyglutarate dehydrogenase (D-2HGDH) catalyzes the specific and efficient oxidation of D-2-hydroxyglutarate (D-2HG) to 2-oxoglutarate using FAD as a cofactor. In this work, we demonstrate that D-2HGDH localizes to plant mitochondria and that its expression increases gradually during developmental and dark-induced senescence in Arabidopsis thaliana, indicating an enhanced demand of respi...

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2-Hydroxyglutarate is not a metabolite; D-2-hydroxyglutarate and L-2-hydroxyglutarate are!

In the recent study by Wang et al. (1), the prognostic significance of the assessment of serum 2-hydroxyglutarate (2-HG) concentrations in acute myeloid leukemia was investigated. The authors report that in 87% of the patients with high serum concentrations of 2-HG, mutations in isocitrate dehydrogenase (IDH)1/IDH2 occurred, versus 29% in the group with moderately high 2-HG concentrations. This...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 2011

ISSN: 0021-9258

DOI: 10.1074/jbc.m110.194175