Placental Development and Endogenous Retroviruses
نویسندگان
چکیده
منابع مشابه
Genomic vagabonds: endogenous retroviruses and placental evolution.
Endogenous retroviruses (ERVs) appear to have a particular predilection for placentas: retroviral genes have repeatedly been coopted for placental functions. In this issue, Chuong draws attention to the important contribution of retroviral promoters in rewiring placental development [1]. He proposes that trophoblast cells provide a permissive epigenetic environment for ERV activity because plac...
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Endogenous retroviruses (ERVs) are fixed and abundant in the genomes of vertebrates. Circumstantial evidence suggests that ERVs play a role in mammalian reproduction, particularly placental morphogenesis, because intact ERV envelope genes were found to be expressed in the syncytiotrophoblasts of human and mouse placenta and to elicit fusion of cells in vitro. We report here in vivo and in vitro...
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Mammalian genomes include a considerable number of endogenous retroviruses (ERVs), relics of ancestral infectious retroviruses, whose proviruses have invaded the germ-line. The documented ability of infectious retroviruses to cause cancer has greatly contributed to the discovery of ERVs. It also reinforced the concept that ERVs are causative agents of many cancers, a notion that historically ha...
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Close to half of the human genome encompasses mobile genetic elements, most of which are retrotransposons. These genetic invaders are formidable evolutionary forces that have shaped the architecture of the genomes of higher organisms, with some conserving the ability to induce new integrants within their hosts' genome. Expectedly, the control of endogenous retroviruses is tight and multi-pronge...
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Endogenous retroviruses are integral features of vertebrate genomes. Here, Hayward and Katzourakis offer a glimpse into the fascinating world of these mysterious partners in our evolution.
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ژورنال
عنوان ژورنال: Uirusu
سال: 2016
ISSN: 0042-6857,1884-3433
DOI: 10.2222/jsv.66.1