Place of the 18F-FDG-PET/CT in the Diagnostic Workup in Patients with Classical Fever of Unknown Origin (FUO)

Objective: To explore the diagnostic contribution of 18F-FDG-PET/CT in a population patients with classical fever unknown origin (FUO), to pinpoint its place decision tree real-life setting, and identify factors associated 18F-FDG-PET/CT. Method: All adult (aged ? 18 years) diagnosis FUO who underwent an University Hospital Montpellier (France) between April 2012 December 2017 were included. True positive 18F-FDG-PET/CT, which evidenced specific disease causing FUO, considered be contributive. Results: Forty-four have been included (20 males, 24 females; mean age 57.5 ± 17.1 years). Diagnoses obtained 31 (70.5%), whom 17 (38.6%) had non-infectious inflammatory diseases, 9 infections (20.5%), 3 malignancies (6.8%). was helpful for making final (true positive) 43.6% all patients. Sensitivity specificity levels 85% 37%, respectively. A total 135 investigations performed before mostly CT scans (93.2%) echocardiography (59.1%), 108 after biopsies (including biopsy temporal artery) (25%) MRIs (34%). In multivariate analysis, hemoglobin level significantly (p = 0.019, OR 0.41; 95% CI (0.20–0.87)), while CRP not contributive Conclusion: may proposed as routine initial non-invasive procedure workup especially anemic could more likely benefit from