PL-08 Enhancing mammalian regeneration

PL-08 Enhancing mammalian regeneration

One of the crucial issues concerning the evolution of animal form is whether there is any general tendency as to the genetic and molecular mechanisms involved? A vast body of comparative studies has revealed that morphology evolves via changes in the spatial regulation of gene expression during development. So the question of the evolution of form boils down to one concerning the evolution of g...

Regeneration of Mammalian Body Parts

Miracle mice When, in 1994, Dr Ellen Heber-Katz of the Wistar Institute in Philadelphia was monitoring marked mice in a group that she used as experimental animals in connection with her research on multiple sclerosis, she received a surprise. The marked mice could not be found! They had punch holes in the ears for identification, and at first it seemed as though a mistake had been made, for no...

Mammalian vestibular hair cell regeneration.

Therapeutic approaches enhancing peripheral nerve regeneration

Peripheral nerve injury is a common occurrence and represents a major economic burden for society. The development of novel strategies to enhance peripheral nerve regeneration is, therefore, of great relevance. Conventional treatments include surgical repair of the damaged nerves for minor injuries, whereas autologous nerve grafts are required to recover longer interruptions. However, despite g...

Enhancing bone marrow regeneration by SALL4 protein

Hematopoietic stem cells (HSCs) are widely used in transplantation therapy to treat a variety of blood diseases. The success of hematopoietic recovery is of high importance and closely related to the patient's morbidity and mortality after Hematopoietic stem cell transplantation (HSCT). We have previously shown that SALL4 is a potent stimulator for the expansion of human hematopoietic stem/prog...