PK-PD correlation of anti-infective agents for dose adjustment in one severe burn child with sepsis

(PK/PD) Modeling of Anti-Neoplastic Agents

Pharmacokinetic/Pharmacodynamic (PK/PD) Modeling of Anti-Neoplastic Agents

Standardization of pharmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs.

Over the last decades, the interest in the relationships between the pharmacokinetics (PK) and pharmacodynamics (PD) of antimicrobial agents has increased and, therefore, the use of PK/PD indices and expressions has spread widely. The appropriate definition and use of these parameters is a matter of controversy. This paper contains a proposal to use PK/PD expressions for antimicrobial agents an...

Pk-pd Integration and Pk-pd Modelling: Alternatives to Dose Titration Studies for Selecting Optimal Dosage Schedules of Antimicrobial Drugs

4. There are universally applicable formulae for systemically acting (including antimicrobial) drugs which: (a) define the relationship between the 3 pivotal pharmacokinetic (PK) parameters, clearance, volume of distribution and elimination half-life; (b) define drug action (pharmacodynamics, PD) quantitatively through the sigmoidal Emax equation, linking concentration to effect; (c) predict a ...

PK/PD modeling supports the dose-escalation decision in VIKING

In the VIKING study a 50 mg once daily regimen of the next generation HIV integrase inhibitor (INI) S/ GSK1349572 (572) exhibited promising antiviral activity in an initial cohort (Cohort I) of treatment-experienced subjects with documented raltegravir (RAL) resistance. The purpose of this work was to evaluate via simulation techniques whether improved virologic responses could be achieved with...