Pituitary-Adrenal Axis During Human Development
نویسندگان
چکیده
منابع مشابه
Pituitary-Adrenal Axis During Human Development
Investigation of early human fetal tissue has helped us elucidate the onset of the activation of the pituitary-adrenal axis during human development. Adrenal steroidogenesis and ACTH secretion from the pituitary starts at 7-8 weeks postconception, providing the rationale for prenatal treatment using dexamethasone offered to fetuses at risk of 21-hydroxylase deficiency (21-OHD). Fluctuation of 3...
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Permanent brain injury is a complication of recurrent hypoglycemia during development. Recurrent hypoglycemia also has adverse consequences on the neuroendocrine system. Hypoglycemia-associated autonomic failure, characterized by ineffective glucose counterregulation during hypoglycemia, is well described in children and adults on insulin therapy for diabetes mellitus. Whether recurrent hypogly...
متن کاملDevelopment of the pituitary adrenal axis in fetal sheep twins.
Plasma cortisol increases in fetuses at term and is important for overall development. This study was designed to determine whether cortisol increases synchronously in twin fetal sheep and whether differences between twins contribute to the respective timing. Catheters were surgically implanted in fetal arteries in twins, the amniotic sac, and a maternal artery and vein. Blood was drawn daily u...
متن کاملDevelopment of the fetal pituitary-adrenal axis in the sheep.
In the ovine fetus, plasma levels of corticosteroids are very low between 60 and 130 days of gestation, then increase dramatically before birth. ACTH appears to be an important regulating hormone for the fetal adrenal cortex, the sensitivity of which to this hormone increases during late gestation. However, the relationship between immunoreactive ACTH and corticosteroids in the fetus is unclear...
متن کاملPituitary-Adrenal Axis in Prader Willi Syndrome
PURPOSE Prader Willi syndrome (PWS) is a rare genetic condition that has concurrent endocrinological insufficiencies. The presence of growth hormone deficiency has been well documented, but adrenal insufficiency (AI) is not widely reported. A review was conducted to investigate its prevalence and relevance in PWS in both adults and children. METHODOLOGY A literature review was performed with ...
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ژورنال
عنوان ژورنال: Clinical Pediatric Endocrinology
سال: 2007
ISSN: 0918-5739,1347-7358
DOI: 10.1297/cpe.16.37