Pitfalls, prevention, and treatment of hyperuricemia during tumor lysis syndrome in the era of rasburicase (recombinant urate oxidase)
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چکیده
منابع مشابه
Pitfalls, prevention, and treatment of hyperuricemia during tumor lysis syndrome in the era of rasburicase (recombinant urate oxidase)
Along with hydration and urinary alkalinization, allopurinol has been the standard agent for the management of hyperuricemia in patients with a high tumor burden at risk of tumor lysis syndrome; however, this agent often fails to prevent and treat this complication effectively. Rasburicase (recombinant urate oxidase) has been shown to be effective in reducing uric acid and preventing uric acid ...
متن کاملEffects of Recombinant Urate Oxidase (Rasburicase) and Allopurinol for Prophylaxis and Treatment of Hyperuricemia in Patients with Leukemia and Lymphoma
Background: Efficacy of rasburicase in pediatric patients with leukemia and lymphoma is proved. This study aims toweigh efficacy and safety of rasburicase versus more conventional therapy, allopurinol, and to compare their safetyand properties in tumor lysis syndrome (TLS) of leukemia and lymphoma patients.Materials and Methods: The study was done with a retrospective cohort design. Patients we...
متن کاملThe Efficacy of Single Dose Rasburicase in Prevention or Treatment of Tumor Lysis Syndrome in Children
Background: Tumor lysis syndrome (TLS) is a major metabolic complication in patients with malignancy after initiation of chemotherapy or spontaneously without treatment. The role of Rasburicase (a recombinant urate-oxidase enzyme) in prevention and treatment of TLS has been demonstrated in recent years. We aimed to investigate the efficacy of a single dose of rasburicase in reducing the risk of...
متن کاملRasburicase for prevention of hyperuricemia and tumor lysis syndrome.
• Hyperuricemia associated with tumor lysis syndrome is a potentially serious complication most frequently seen during chemotherapy for malignancies with large tumor burden and highly proliferative cells, such as aggressive lymphomas and leukemia.1-3 Hyperuricemia usually occurs in association with other metabolic abnormalities, including hyperphosphatemia, hyperkalemia, hypocalcemia, and azote...
متن کاملeffects of recombinant urate oxidase (rasburicase) and allopurinol for prophylaxis and treatment of hyperuricemia in patients with leukemia and lymphoma
background: efficacy of rasburicase in pediatric patients with leukemia and lymphoma is proved. this study aims toweigh efficacy and safety of rasburicase versus more conventional therapy, allopurinol, and to compare their safetyand properties in tumor lysis syndrome (tls) of leukemia and lymphoma patients.materials and methods: the study was done with a retrospective cohort design. patients we...
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ژورنال
عنوان ژورنال: Biologics: Targets & Therapy
سال: 2008
ISSN: 1177-5475
DOI: 10.2147/btt.s1522