Pilot Study of Oral Valganciclovir Therapy in Patients With Classic Kaposi Sarcoma
نویسندگان
چکیده
منابع مشابه
Pilot study of oral valganciclovir therapy in patients with classic Kaposi sarcoma.
We conducted a clinical trial of oral valganciclovir, a drug with in vitro activity against Kaposi sarcoma (KS)-associated herpesvirus (KSHV), in classic KS. Five human immunodeficiency virus-seronegative participants received valganciclovir for up to six 4-week cycles at doses used for cytomegalovirus infection. None of the study subjects showed an objective response; KS progressed in 4 subjec...
متن کاملClassic Kaposi sarcoma.
sented with a four-year history of asymp tomatic lesions on his legs. On examination, he had violaceous infiltrated areas on his feet and below his knees (Figure 1A; Appendix 1, available at www.cmaj.ca /lookup /suppl /doi:10.1503 /cmaj.101646/-/DC1). Histology confirmed a diagnosis of Kaposi sarcoma (Appendix 2, available at www.cmaj.ca /lookup /suppl/doi:10.1503/cmaj.101646/-/DC1), and immuno...
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Kaposi sarcoma is a malignant disease that originates fromthe lymphatic system. Different epidemiological, clinical andhistopathological variants of this neoplasm have been identified.Classic Kaposi sarcoma is one of the four main clinico-epidemiologicvariants. Cutaneous lesions vary from pink patches to darkviolet plaques, nodules or polyps, depending on clinical variantand stage. Kaposi sarco...
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Kaposi sarcoma, in view of its benign and chronic nature, is usually now considered to be a vascular hyperplasia rather than a true tumor. It is always linked to Human herpesvirus (HHV) 8, which is a necessary though alone insufficient condition for the development of the lesions.1 Four variants have been described: classic, endemic African, immunosuppression-associated, and human immunodeficie...
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increased by about 75% between 1999 and 2004; the total number of cases was 675 per 100 000 inhabitants in 1999 and 1156 in 2004. Cases of congenital syphilis have increased 700%, rising from 2 in 1999 to 16 in 2004, with 9 cases reported in 2000, 8 in 2001, 15 in 2002, and 4 in 2003. In 2004 the number of reports has continued to climb, with 12 cases described in the province of Malaga alone.3...
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ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2011
ISSN: 1537-6613,0022-1899
DOI: 10.1093/infdis/jiq177